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An fMRI study of theory of mind in individuals with first episode psychosis.

Identifieur interne : 001056 ( Main/Exploration ); précédent : 001055; suivant : 001057

An fMRI study of theory of mind in individuals with first episode psychosis.

Auteurs : Cali F. Bartholomeusz [Australie] ; Eleni P. Ganella [Australie] ; Sarah Whittle [Australie] ; Kelly Allott [Australie] ; Andrew Thompson [Royaume-Uni] ; Ahmad Abu-Akel [Suisse] ; Henrik Walter [Allemagne] ; Patrick Mcgorry [Australie] ; E In Killackey [Australie] ; Christos Pantelis [Australie] ; Stephen J. Wood [Royaume-Uni]

Source :

RBID : pubmed:30212786

Descripteurs français

English descriptors

Abstract

Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the greatest impact on functional outcome in schizophrenia. It is not yet known if neural abnormalities underlying ToM present early, during the first episode of psychosis (FEP). Fourteen FEP participants and twenty-two healthy control participants, aged 15-25, were included in analyses. All participants had a 3T magnetic resonance imaging scan and completed a block-design picture-story attribution-of-intentions ToM fMRI task, and completed a battery of behavioral social cognitive measures including a ToM task. General linear model analyses were carried out. Post-hoc regression analyses were conducted to explore whether aberrant ToM-related activation in FEP participants was associated with symptomatology and global social and occupational functioning. FEP participants, when compared to healthy controls, had significantly less activity in the right temporoparietal junction, right orbitofrontal cortex and left middle prefrontal/inferior frontal cortex, when making social attributions. Aberrant ToM-related activation in the right temporoparietal junction was associated with severity of overall psychopathology, but not functional outcome. Specific regions of the social brain network, associated with ToM, are dysfunctional in young people with FEP. Future research should determine whether alteration of normal brain functioning in relation to ToM occurs before or during illness onset.

DOI: 10.1016/j.pscychresns.2018.08.011
PubMed: 30212786


Affiliations:


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Le document en format XML

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<term>Male</term>
<term>Neuropsychological Tests</term>
<term>Regression Analysis</term>
<term>Social Behavior</term>
<term>Social Perception</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adolescent</term>
<term>Adulte</term>
<term>Analyse de régression</term>
<term>Comportement social</term>
<term>Femelle</term>
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<div type="abstract" xml:lang="en">Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the greatest impact on functional outcome in schizophrenia. It is not yet known if neural abnormalities underlying ToM present early, during the first episode of psychosis (FEP). Fourteen FEP participants and twenty-two healthy control participants, aged 15-25, were included in analyses. All participants had a 3T magnetic resonance imaging scan and completed a block-design picture-story attribution-of-intentions ToM fMRI task, and completed a battery of behavioral social cognitive measures including a ToM task. General linear model analyses were carried out. Post-hoc regression analyses were conducted to explore whether aberrant ToM-related activation in FEP participants was associated with symptomatology and global social and occupational functioning. FEP participants, when compared to healthy controls, had significantly less activity in the right temporoparietal junction, right orbitofrontal cortex and left middle prefrontal/inferior frontal cortex, when making social attributions. Aberrant ToM-related activation in the right temporoparietal junction was associated with severity of overall psychopathology, but not functional outcome. Specific regions of the social brain network, associated with ToM, are dysfunctional in young people with FEP. Future research should determine whether alteration of normal brain functioning in relation to ToM occurs before or during illness onset.</div>
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<Year>2019</Year>
<Month>07</Month>
<Day>25</Day>
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<Year>2019</Year>
<Month>07</Month>
<Day>25</Day>
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<ISSN IssnType="Electronic">1872-7506</ISSN>
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<Volume>281</Volume>
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<Year>2018</Year>
<Month>11</Month>
<Day>30</Day>
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<Title>Psychiatry research. Neuroimaging</Title>
<ISOAbbreviation>Psychiatry Res Neuroimaging</ISOAbbreviation>
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<ArticleTitle>An fMRI study of theory of mind in individuals with first episode psychosis.</ArticleTitle>
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<AbstractText>Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the greatest impact on functional outcome in schizophrenia. It is not yet known if neural abnormalities underlying ToM present early, during the first episode of psychosis (FEP). Fourteen FEP participants and twenty-two healthy control participants, aged 15-25, were included in analyses. All participants had a 3T magnetic resonance imaging scan and completed a block-design picture-story attribution-of-intentions ToM fMRI task, and completed a battery of behavioral social cognitive measures including a ToM task. General linear model analyses were carried out. Post-hoc regression analyses were conducted to explore whether aberrant ToM-related activation in FEP participants was associated with symptomatology and global social and occupational functioning. FEP participants, when compared to healthy controls, had significantly less activity in the right temporoparietal junction, right orbitofrontal cortex and left middle prefrontal/inferior frontal cortex, when making social attributions. Aberrant ToM-related activation in the right temporoparietal junction was associated with severity of overall psychopathology, but not functional outcome. Specific regions of the social brain network, associated with ToM, are dysfunctional in young people with FEP. Future research should determine whether alteration of normal brain functioning in relation to ToM occurs before or during illness onset.</AbstractText>
<CopyrightInformation>Copyright © 2018. Published by Elsevier B.V.</CopyrightInformation>
</Abstract>
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<LastName>Bartholomeusz</LastName>
<ForeName>Cali F</ForeName>
<Initials>CF</Initials>
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<Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville 3053, Victoria, Australia; The Centre for Youth Mental Health, The University of Melbourne, Victoria, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia. Electronic address: cali.bartholomeusz@orygen.org.au.</Affiliation>
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<Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville 3053, Victoria, Australia; The Centre for Youth Mental Health, The University of Melbourne, Victoria, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
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<LastName>Whittle</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Allott</LastName>
<ForeName>Kelly</ForeName>
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<AffiliationInfo>
<Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville 3053, Victoria, Australia; The Centre for Youth Mental Health, The University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
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<Affiliation>Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, United Kingdom.</Affiliation>
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<LastName>Abu-Akel</LastName>
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<Affiliation>Institute of Psychology, University of Lausanne, Lausanne, Switzerland.</Affiliation>
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</Author>
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<ForeName>Henrik</ForeName>
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<Affiliation>Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Berlin University of Medicine, corporate member of Free University of Berlin, Humboldt University of Berlin, and Berlin Institute of Health, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>McGorry</LastName>
<ForeName>Patrick</ForeName>
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<Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville 3053, Victoria, Australia; The Centre for Youth Mental Health, The University of Melbourne, Victoria, Australia.</Affiliation>
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<LastName>Killackey</LastName>
<ForeName>Eóin</ForeName>
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<Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville 3053, Victoria, Australia; The Centre for Youth Mental Health, The University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Pantelis</LastName>
<ForeName>Christos</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia; Centre for Neural Engineering (CfNE), Department of Electrical and Electronic Engineering, University of Melbourne, Carlton South, Victoria, Australia; Florey Institute for Neuroscience & Mental Health, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
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<LastName>Wood</LastName>
<ForeName>Stephen J</ForeName>
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<AffiliationInfo>
<Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville 3053, Victoria, Australia; The Centre for Youth Mental Health, The University of Melbourne, Victoria, Australia; School of Psychology, University of Birmingham, Birmingham, United Kingdom.</Affiliation>
</AffiliationInfo>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<Year>2018</Year>
<Month>08</Month>
<Day>23</Day>
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<Country>Netherlands</Country>
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<MeshHeading>
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<MeshHeading>
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